Fractional flow reserve (FFR) measures blood flow reduction caused by vessel narrowing. It is measured invasively using a guide wire-based cardiac catheter procedure that is performed in a catheterization lab. FFR is accepted as the reference standard for assessing the functional significance of stenotic lesions (Montalescot et al.). However, FFR is not suitable for myocardial ischemia screening in stable patients with coronary artery disease.
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