Specificity is used in combination with sensitivity to evaluate the effectiveness of a software medical device. Specificity is the ability of a software medical device to correctly identify cases without the disease that are being tested. A device with high specificity will correctly rule out patients who do not have the disease without generating many false-positive results.

For example, if a software medical device is reported of having a 95% specificity, it will correctly return a negative result for 95% of patients. However, it will return a positive result for 5% of patients who do not have the disease and should have returned a negative result.

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