CT FFR - Improving Diagnosis & Treatment of Patients with Coronary Artery Disease

DEEPVESSEL FFR is FDA-Cleared, CE-Marked, and NMPA-Approved. 

Fast and acurate non-invasive deep learning-based CT FFR analysis

DEEPVESSEL FFR ( DVFFR) is a software medical device that uses deep learning technology to perform a non-invasive physiological functional assessment of the coronary arteries using coronary computed tomography angiography.

DEEPVESSEL FFR applies Keya Medical’s proprietary deep learning technologies built on the latest advances in computer vision and medical image analysis. This new approach gives a strong performance advantage with fast processing speed and accurate non-invasive FFR analysis.

DeepVessel FFR software displayed on desktop

A New Category I CPT code for non-invasive FFR

Category I CPT Code

Starting January 1, 2024, medical practices will implement a new category I CPT code (75580) for non-invasive FFR estimates derived from coronary CT angiography software analysis.

The American College of Cardiology (ACC), American College of Radiology (ACR), and the Society of Cardiovascular Computed Tomography (SCCT) jointly proposed this change to the American Medical Association. It replaces four prior category III CPT codes.

Utilizing deep learning algorithms, CT FFR analysis with DeepVessel generates a 3D coronary artery model and simulates FFR values across the entire coronary tree.

Payment for FFR-CT services in hospital settings is now approximately 7% higher, according to the Centers for Medicare and Medicaid Services (CMS).
Code 75580 is applicable in hospital outpatient facilities, physician offices, and imaging centers. RVUs have been allocated for FFR-CT services as well.

New Path to Diagnose Coronary Artery Disease

The path of diagnosis of CAD with CT FFR starts with Coronary Computer Tomography Angiography (CCTA). CCTA is sent to Keya Medical. AI algorithms, and certified by Keya Medical analysts perform the DV FFR analysis. Interactive 3-D model of coronary arteries and PDF report with mapped FFR values are electronically delivered to clinicians. The analysis is accessible on stationary or mobile devices.

Coronary CTA


CT FFR Analysis


CT FFR Results

Ambra Health Workflow

Ambra KM Workflow
  1. Upload and de-identification of DICOM data on Ambra platform
  2. Transfer of de-identified DICOM data to Keya Medical via Ambra’s US-based AWS servers.
  3. CT FFR analysis and generation of PDF report and 3D interactive model
  4. Upload of the CT FFR analysis results on Ambra platform

DEEPVESSEL Analysis Steps



Coronary 3D Model
FFR Calculation


Coronary FFR

Improved Patient Care and Management

FFRCT and DVFFR have transformed my practice, allowing me to provide superior patient care and achieve better outcomes. I am sincerely grateful for this invaluable resource provided by Corazon Imaging.

John A. Rumberger, PhD, MD, FACC, MSCCT
Medical Director, Corazon Imaging



90% diagnostic accuracy using invasive FFR as the ground truth


Provides anatomical and functional information at every point of the coronary tree

Cost Saving

Offers patient- and payer-centric pricing

Physician Autonomy

Physicians decide when to utilize CT FFR analysis

Streamlined Workflow

No certification of scanners, software maintenance, or staff training


Provides rapid results for timely decision-making

Product Features


Non-invasive functional assessment from CTA scan


Enables accurate and fast FFR analysis


Provides both anatomical and functional information


Novel coronary CT FFR technique driven by AI

Accessible on mobile, PC, and tablet devices

FDA cleared
CE marked

Clinical Trials Performance Assessment

Multi-national multi-center clinical validation study ADAPT [1] 2021

  • DVFFR analysis was conducted on a total of 269 patients with 358 target vessels from 10 clinical sites (5 from US and 5 from EU)
  • Primary endpoint: per-vessel sensitivity and specificity of DVFFR to detect ischemic condition comparing with invasive FFR measurement
  • Study demonstrated that DVFFR yielded good diagnostic performance and met pre-specified criteria for study success


PER-VESSEL Estimate, % 2-Sided 95% CI (lower bound) Target Rate Met/Not Met
Sensitivity 86.9% 80.6% 75% Met
Specificity 86.7% 82.0% 70% Met
PER-VESSEL Estimate, % (95% CI)
Accuracy 86.8%
PPV 79.4%
NPV 91.9%
PER-PATIENT Estimate, % (95% CI)
Sensitivity 87.4% (79.4-93.1%)
Specificity 83.7% (76.5-89.4%)
Accuracy 85.2% (80.2-89.4%)
PPV 79.6% (71.0-86.6%)
NPV 90.1% (83.6-94.6%)
Keya Medical conducted prospective[1] and retrospective multicenter, self-controlled studies in 2017 and 2019. In these trials, FFR measured invasively using a pressure wire was used as the gold standard to evaluate the sensitivity and specificity of DeepVessel FFR in evaluating functional myocardial ischemia in patients with stable coronary artery disease.

2017 Clinical Trial

In 2017, DeepVessel FFR was tested via a multi-center prospective clinical trial in which patients were recruited from:

  • Beijing Anzhen Hospital affiliated to Capital Medical University
  • Air Force General Hospital PLA
  • Cangzhou Central Hospital
Study results demonstrated:
Accuracy 89.2%
Sensitivity 94.2%
Specificity 84.3%
Positive Predictive Value 86.9%
Negative Predictive Value 92.2%

2019 Clinical Trial

In 2019, DeepVessel FFR was tested via a multi-center retrospective clinical trial in which patients were recruited from:

  • Beijing Anzhen Hospital affiliated with Capital Medical University
  • Fuwai Hospital, Chinese Academy of Medical Sciences
  • Beijing Friendship Hospital
  • The First Affiliated Hospital of Wenzhou Medical University
  • The Second Affiliated Hospital of Zhejiang University Medical College
  • Wuhan Asia Heart Hospital
Study results demonstrated:
Accuracy 90.8%
Sensitivity 94.7%
Specificity 88.6%
Positive Predictive Value 83.0%
Negative Predictive Value 96.7%


[1] Wang ZQ, Zhou YJ, Zhao YX, et al. Diagnostic accuracy of a deep learning approach to calculate FFR from coronary CT angiography. J Geriatr Cardiol 2019;16:42-48.

Learn more about DEEPVESSEL FFR